The Macallan Peter Blake 1926 60-year-old went under the hammer in Hong Kong for 7,962,500 HK dollars (£751,703), beating the previous title-holder which sold for around 4.9 million HK dollars (£460,000).
But this was then beaten by a Macallan Valerio Adami 1926 60-year-old which went for 8,636,250 HK dollars (£814,081), according to Bonhams.
Daniel Lam, head of fine wine and whisky at Bonhams Asia, said: "These two bottles are the most significant whiskies ever produced in 20th century and truly presented a once-in-a-generation opportunity for collectors to acquire the Holy Grail of Macallan.
"Active bidding came in from around the world but we saw new bidders from Southeast Asia including Vietnam, Thailand and Malaysia reflecting the growing appetite and appreciation for whisky among Asian collectors and further reinforcing Bonhams market leadership in Hong Kong in the field of whisky."
The record breaking whisky was bottled in 1986.
Macallan commissioned Peter Blake and Valerio Adami to design labels for very limited editions.
They were given as corporate gifts to the distillery's "most valued" customers.
Only 24 bottles - 12 of the Blake label and 12 of the Adami label - were ever produced.
They are presented in specially commissioned cabinets or Tantaluses, based on the traditional "Brass and Glass" distillery spirit safe.
The previous auction record for any Single Malt Whisky was last seen in 2014 in Hong Kong with the sale of the Macallan six-litre "M" Decanter by Lalique, which fetched around 4.9 million HK dollars (£460,000).