The locations of the 15 McDonald's restaurants that will reopen will be announced the week beginning 4 May.
The moves comes after the fast food chain spent a week testing its operations behind closed doors in preparation to reopen sites.
Paul Pomroy, the chain's boss for the UK and Ireland, said the tests proved "successful", allowing the company to "slowly" start to serve customers again.
McDonald's said it has incorporated feedback from staff after the tests and worked closely with the government and trade bodies regarding its reopening plans.
All restaurants will be deep cleaned prior to reopening, with new safety measures such as Perspex screens and floor markings.
Staff will also receive protective equipment, such as non-medical grade face masks, and have their temperatures taken with "contactless thermometers" before shifts.
The chain said it will also introduce "social distancing measures for all delivery and service partners", which include Uber Eats and Just Eat.
The McDonald's restaurants that reopen will do so with much smaller teams, which means a limited menu and, unfortunately for some, no breakfast will be being served.
Paul Pomroy added: "When we return it will be different as we all adjust to this new normal. I want to apologise in advance if our first wave of reopened restaurants does not serve your area.
"Rest assured, we are working hard to reopen more restaurants, but I am adamant this must be at the right pace with the wellbeing of our employees, suppliers and customers front of mind.
"Slowly, but safely, we will return to towns and cities across the UK and Ireland and thank-you for your continued support as we work through this crisis."
This announcement comes as it was reported that Greggs has pulled back on plans to reopen its first sites to the public over fears it could attract crowds.