The Deadpool star is joined by David Beckham, whose Haig Club whisky is also owned by Diageo, and Diddy, with the video showing the trio trying a cocktail that they've created in an 'industry first'.
The 'daring combination' includes One part DeLeón Tequila, Haig Club and Aviation Gin. The video cuts to Ryan, Diddy and David taking a drink before spitting the drink out.
After a string of expletives from Ryan, and Diddy proclaiming 'that s**t tastes like assfeet', David says: "Ryan this is not going to work, why did we think we could do this?"
The video ends stating 'this is why we need mixologists, and why we are donating $1 million to their causes - Bartenders Benevolent Fund, The Drinks Trust and Another Round Another Rally.
This move comes almost a year on since Diaego announced a $100 million global programme to support pubs and bars titled“Raising the Bar", with nearly £30million being made available for pubs and bars across the UK, and £4million of that targeted at Scotland.
More recently, more than 160 bar staff across Scotland have utilised the support from the brand's Learning for Life Hospitality Elevator programme.
Delivered in partnership with the charity Springboard, Diageo’s Hospitality Elevator virtual programme has been designed to provide specialist support to people working in the sector.
In Scotland The BEN has raised money via auctions and benefited from donations from distilleries.
The charity supports people of all ages who have worked in the licensed trade, with beneficiaries receiving annual financial assistance as well as discretionary one-off grants for emergency situations.
In 2019 Beckham was spotted around Scotland as he filmed a series of videos for Haig Club.
On the journey, David reconnected with the team behind the making of Haig Club as well as meeting local Glasgow bar owners who make their own rules when it comes to Scotch, playing their part in helping to re-evaluate the preconceptions of traditional whisky cocktail making.